ANTITUMOR EFFECT OF 4MU ON GLIOBLASTOMA CELLS IS MEDIATED BY SENESCENCE INDUCTION AND CD44, RHAMM AND P-ERK MODULATION

Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation

Abstract The extracellular matrix plays a key role in cancer progression.Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes.Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as MEK/ERK.4-methylumbelliferone (4MU), a well

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Arthroscopically Assisted Reconstruction of Lateral Metatarsosesamoid Suspensory and Lateral Metatarsophalangeal Collateral Ligaments in the Management of Iatrogenic Hallux Varus Deformity

The medial and lateral metatarsosesamoid suspensory ligaments together with the sesamoid apparatus are the main contributors to the rotational stability of the first metatarsophalangeal joint (MTPJ).Rotational instability of first MTPJ is a major factor in the development of hallux valgus and varus deformities.As the great toe starts to rotate, the

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